Rapid visual detection of blood cyanide

Stabilization of blood cyanide.

The measurement of blood cyanide is of clinical importance because, aside from the relatively few cases of accidental or selfinduced poisoning, raised levels are found in patients receMng the hypotensive agent sodium nitroprusside (1), in victims of smoke inhalation injury (2), and in lx~pulations at risk of ataxic mydopathy in areas of high cassava consumption C,). However, very few hospital l...

Hydrogen cyanide related deaths and detection in the blood.

Rapid detection of positive blood cultures.

A study of 16,108 blood cultures investigated the value of performing early smears in addition to the inspection of early subcultures after 12 h of incubation. The early smear and subculture detected 44.6% of 1,236 positive cultures; of those detected by the early subculture, 57.3% grew after 12 h of incubation.

Rapid point of care analyzer for the measurement of cyanide in blood.

A simple, sensitive optical analyzer for the rapid determination of cyanide in blood in point of care applications is described. HCN is liberated by the addition of 20% H(3)PO(4) and is absorbed by a paper filter impregnated with borate-buffered (pH 9.0) hydroxoaquocobinamide (hereinafter called cobinamide). Cobinamide on the filter changes color from orange (λ(max) = 510 nm) to violet (λ(max) ...

A disposable blood cyanide sensor.

Deaths due to smoke inhalation in fires are often due to poisoning by HCN. Rapid administration of antidotes can result in complete resuscitation of the patient but judicious dosing requires the knowledge of the level of cyanide exposure. Rapid sensitive means for blood cyanide quantitation are needed. Hydroxocyanocobinamide (OH(CN)Cbi) reacts with cyanide rapidly; this is accompanied by a larg...